It is bounded by Guainía department (north), Brazil (east), the Apoporis River (south), and Guaviare department (west).
The capital is Mitú; Vaupés has 3 municipalities.
The main economic activities of Vaupés are subsistence agriculture, fishing, forestry, and the collection of plants for medicinal and traditional purposes.
The first conquistador in arriving to this department was Hernán Pérez de Quesada in 1538.
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